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CRSP Stock Risk & Deep Value Analysis

CRISPR Therapeutics AG

Healthcare β€’ Biotechnology

DVR Score

8.6

out of 10

Hidden Gem

What You Need to Know About CRSP Stock

We analyzed CRISPR Therapeutics AG using our deep value framework. Sign in to see our full verdict and DVR Score.

We ran CRSP through our deep value framework β€” analyzing financial health, distress signals, competitive moat, and risk factors. Our risk assessment: Aggressive. Here's what we found.

Updated Mar 24, 2026β€’Run Fresh Analysis β†’

CRSP Risk Analysis & Red Flags

Risk Matrix

Overall

Aggressive

Financial

Medium

Market

Medium

Competitive

Medium

Execution

Medium

Regulatory

High

Upcoming Risk Events

  • πŸ“…

    Slower-than-expected CASGEVY commercial ramp-up

  • πŸ“…

    Clinical trial failures or significant delays for pipeline assets

  • πŸ“…

    Increased competition in gene editing space

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What Does CRISPR Therapeutics AG (CRSP) Do?

Market Cap

$4.44B

Sector

Healthcare

Industry

Biotechnology

Employees

393

CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious human diseases using its Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. The company's CRISPR/Cas9 is a revolutionary technology for gene editing which is the process of precisely altering specific sequences of genomic DNA. It has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, CAR T cell therapies, in vivo, and type 1 diabetes, as well as develops investigational CAR T programs, including an autologous, gene-edited CAR T program targeting glypican-3 (GPC3) for the potential treatment of solid tumors. The company's lead product candidate is CASGEVY, an ex vivo CRISPR/Cas9 gene-edited cell therapy for treating patients suffering from transfusion-dependent beta-thalassemia, severe sickle cell disease (SCD), and hemoglobinopathies in which a patient's hematopoietic stem and progenitor cells are edited to produce high levels of fetal hemoglobin in red blood cells. It also develops CAR T cell therapies, including CTX112 targeting cluster of differentiation 19 (CD19) and CTX131 targeting CD70 for oncology and autoimmune indications; CTX310 and CTX320, in vivo gene editing to address the cardiovascular disease by disrupting the validated targets angiopoietin-like protein 3 and lipoprotein; and CTX211, an allogeneic, gene-edited, hypoimmune stem cell-derived product candidate for the treatment of T1D. It has strategic partnerships with Vertex Pharmaceuticals Incorporated, Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.

Visit CRISPR Therapeutics AG Website

Investment Thesis

CRISPR Therapeutics represents a high-risk, high-reward investment in a transformative biotech sector. Its pioneering gene-editing technology, the first-to-market CASGEVY, and a robust, advancing pipeline, all supported by a strengthened balance sheet, position it as a potential long-term leader in curing genetic diseases. Despite early commercialization challenges, insider selling, and valuation concerns, its long-term potential for market disruption remains significant.

Is CRSP Stock Undervalued?

CRISPR Therapeutics remains a high-potential player in gene editing, positioned for transformative growth. The successful commercialization of Casgevy (with Vertex) and planned pediatric filings in H1 2026 solidify its market entry and de-risk early revenue generation, albeit with a reported ~97.8% YoY revenue decline in an unspecified recent period, indicating challenges in early commercial ramp-up. The recent $550 million convertible notes offering significantly bolsters its balance sheet to $2.56 billion pro forma cash, providing a long runway for its extensive and advancing pipeline in oncology and *in vivo* gene editing. While insider selling and potential dilution from the convertible notes are watch items, and the company remains pre-profitability, its formidable IP, strategic alliance, and first-mover advantage in approved gene therapies sustain its high potential for 10x growth within 3-5 years, despite current commercial execution hurdles.

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CRSP Price Targets & Strategy

12-Month Target

$90.00

Bull Case

$150.00

Bear Case

$35.00

Valuation Basis

Implied valuation based on projected pipeline success, increasing CASGEVY market penetration, and peer growth multiples applied to estimated future revenue streams, targeting early-stage commercial biotech valuations.

Entry Strategy

Consider dollar-cost averaging between $40-$48, taking advantage of current price near 52-week lows and below 50-day MA ($53.26).

Exit Strategy

Take partial profits at $90-$100, re-evaluate upon major pipeline catalysts. Implement a stop loss below $39.00 (below 52-week low of $30.04 to allow for volatility).

Portfolio Allocation

7-10% for aggressive risk tolerance

Price Targets & Strategy

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Is CRSP Financially Healthy?

Valuation

P/E Ratio

-7.09

Profitability

Return on Equity

-26.31%

Revenue Growth

-97.60%

EPS

$-1.37

Balance Sheet

Current Ratio

13.30

Debt/Equity

0.11

Total Debt

$550.00M

Other

Beta (Volatility)

1.72

Does CRSP Have a Competitive Moat?

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Moat Rating

πŸ›‘οΈ Narrow

Moat Trend

Expanding

Moat Sources

3 Identified

Intangible Assets/IP (CRISPR/Cas9 patent estate)Switching Costs (high development cost, regulatory hurdles, patient-specific nature of gene therapies)First-Mover Advantage (CASGEVY approval)

CRISPR Therapeutics' moat is primarily derived from its foundational IP in gene editing and its early lead in bringing a therapy to market. This creates a significant head start, but patent challenges and emerging alternative technologies could erode its durability over the long term. Continued pipeline success and expansion of indications will strengthen this moat.

Moat Erosion Risks

  • β€’Potential invalidation or erosion of key IP through legal challenges
  • β€’Emergence of superior or more cost-effective gene-editing technologies from competitors
  • β€’Difficulty in scaling manufacturing or overcoming regulatory hurdles for new therapies

CRSP Competitive Moat Analysis

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CRSP Market Intelligence

Sentiment & Insider Activity

Social Sentiment

Neutral, with potential for increased retail interest on positive news.

Institutional Sentiment

Positive, indicated by analyst target raises from Piper Sandler and Chardan Capital, despite some Hold ratings.

Insider Activity (Form 4)

Negative: CEO and General Counsel among those who sold approximately 128,626 shares worth ~$7.13 million in the last 90 days.

Options Flow

Normal options activity.

Earnings Intelligence

Next Earnings

2026-05-06 (Q1 2026 estimated)

Surprise Probability

Medium

Historical Earnings Pattern

Specific historical earnings reaction patterns are not provided in the search results, but early-stage biotech stocks typically exhibit high volatility around clinical and commercial updates.

Key Metrics to Watch

CASGEVY patient starts and revenue contributionUpdates on pipeline progression (especially Phase 1 studies)Cash burn rate and pro forma cash runway guidance

Competitive Position

Top Competitor

Vertex Pharmaceuticals (VRTX)

Market Share Trend

Gaining (as a first-mover in approved gene-editing therapy for specific indications with CASGEVY).

Valuation vs Peers

Trading at a significant premium to traditional profitability metrics (negative P/E) but in line with early-stage, high-growth biotech based on future revenue potential. GF Valueβ„’ indicates 'Significantly Overvalued' based on intrinsic value estimates.

Competitive Advantages

  • β€’Pioneering CRISPR/Cas9 technology and strong intellectual property portfolio
  • β€’First-mover advantage with an approved gene-editing therapy (CASGEVY)
  • β€’Strategic and commercial alliance with Vertex Pharmaceuticals for CASGEVY

Market Intelligence

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What Could Drive CRSP Stock Higher?

Near-Term (0-6 months)

  • β€’Q1 2026 Earnings on Wednesday, May 6, 2026
  • β€’CASGEVY pediatric regulatory filings (H1 2026)
  • β€’CTX340 Phase I initiation (H1 2026)

Medium-Term (6-18 months)

  • β€’Zugo-cel Phase I initiation (H2 2026)
  • β€’CTX460 Phase I initiation (mid-2026)
  • β€’Initial CASGEVY pediatric approvals and market launch

Long-Term (18+ months)

  • β€’Expansion of CASGEVY into additional indications or geographies
  • β€’Multiple new product approvals from diverse pipeline assets
  • β€’Industry leadership in *in vivo* gene editing therapies

Catalysts & Growth Drivers

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What's the Bull Case for CRSP?

  • βœ“

    Acceleration in CASGEVY patient enrollment and revenue figures

  • βœ“

    Positive clinical trial data for CTX programs, especially in oncology and *in vivo* applications

  • βœ“

    New strategic partnerships or major milestone payments

Bull Case Analysis

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Competing with CRSP

See how CRISPR Therapeutics AG compares to related companies

CompanyMarket CapDVR ScoreP/ERevenueProfit MarginRev Growth

CRISPR Therapeutics AG

CRSP

$4.4B8.6-7.1$3.5M0.0%-97.6%

AbbVie Inc

ABBV

$403.8B0.1171.8β€”β€”β€”Compare β†’

Johnson & Johnson

JNJ

β€”1.0β€”β€”β€”β€”Compare β†’

Eli Lilly and Co

LLY

$965.0B0.552.6β€”β€”β€”Compare β†’

Pfizer Inc

PFE

$150.6B0.219.4$62.6B12.4%-1.6%Compare β†’

UnitedHealth Group Inc

UNH

$276.2B0.322.9$113.7B2.7%1181.0%Compare β†’

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FAQ

What is the DVR Score for CRISPR Therapeutics AG (CRSP)?

As of March 24, 2026, CRISPR Therapeutics AG has a DVR Score of 8.6 out of 10, placing it in the "Hidden Gem" category. This score is generated by our AI-powered deep value analysis framework that evaluates growth potential, financial health, competitive moat, and risk factors.

What is the market capitalization of CRISPR Therapeutics AG?

CRISPR Therapeutics AG's market capitalization is approximately $4.4B. The company operates in the Healthcare sector within the Biotechnology industry.

What ticker symbol does CRISPR Therapeutics AG use?

CRSP is the ticker symbol for CRISPR Therapeutics AG. The company trades on the NGM.

What is the risk level for CRSP stock?

Our analysis rates CRISPR Therapeutics AG's overall risk as Aggressive. This assessment considers execution risk, market risk, financial risk, competitive risk, and regulatory risk. For a full breakdown, see the risk analysis section above.

What is the P/E ratio of CRSP?

CRISPR Therapeutics AG currently has a price-to-earnings (P/E) ratio of -7.1. This is below the market average, which could indicate the stock is undervalued or facing headwinds.

Is CRISPR Therapeutics AG's revenue growing?

CRISPR Therapeutics AG has reported revenue growth of -97.6%. Revenue has been declining, which warrants closer examination.

Is CRSP stock profitable?

CRISPR Therapeutics AG has a profit margin of 0.0%. The company is currently unprofitable.

How often is the CRSP DVR analysis updated?

Our AI-powered analysis of CRISPR Therapeutics AG is refreshed regularly to incorporate the latest financial data, market conditions, and news. The most recent update was on March 24, 2026.

Important Disclaimer – Not Financial Advice

Deep Value Reports is an independent research platform for educational and informational purposes only. We are not financial advisors, investment advisors, or licensed professionals. The analysis, scores, and information provided on this page for CRSP (CRISPR Therapeutics AG) should not be construed as personalized investment advice, a recommendation to buy or sell any security, or an offer to provide investment advisory services.

All investments involve risk, including the potential loss of principal. Past performance does not guarantee future results. Always conduct your own research, consider your financial situation, and consult with a qualified financial advisor before making any investment decisions.

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