CRSP Stock Risk & Deep Value Analysis
CRISPR Therapeutics AG
Healthcare β’ Biotechnology
DVR Score
out of 10
What You Need to Know About CRSP Stock
We analyzed CRISPR Therapeutics AG using our deep value framework. Sign in to see our full verdict and DVR Score.
We ran CRSP through our deep value framework β analyzing financial health, distress signals, competitive moat, and risk factors. Our risk assessment: Aggressive. Here's what we found.
CRSP Risk Analysis & Red Flags
Risk Matrix
Overall
Aggressive
Financial
Medium
Market
Medium
Competitive
Medium
Execution
Medium
Regulatory
High
Upcoming Risk Events
- π
Slower-than-expected CASGEVY commercial ramp-up
- π
Clinical trial failures or significant delays for pipeline assets
- π
Increased competition in gene editing space
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What Does CRISPR Therapeutics AG (CRSP) Do?
Market Cap
$4.44B
Sector
Healthcare
Industry
Biotechnology
Employees
393
CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious human diseases using its Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. The company's CRISPR/Cas9 is a revolutionary technology for gene editing which is the process of precisely altering specific sequences of genomic DNA. It has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, CAR T cell therapies, in vivo, and type 1 diabetes, as well as develops investigational CAR T programs, including an autologous, gene-edited CAR T program targeting glypican-3 (GPC3) for the potential treatment of solid tumors. The company's lead product candidate is CASGEVY, an ex vivo CRISPR/Cas9 gene-edited cell therapy for treating patients suffering from transfusion-dependent beta-thalassemia, severe sickle cell disease (SCD), and hemoglobinopathies in which a patient's hematopoietic stem and progenitor cells are edited to produce high levels of fetal hemoglobin in red blood cells. It also develops CAR T cell therapies, including CTX112 targeting cluster of differentiation 19 (CD19) and CTX131 targeting CD70 for oncology and autoimmune indications; CTX310 and CTX320, in vivo gene editing to address the cardiovascular disease by disrupting the validated targets angiopoietin-like protein 3 and lipoprotein; and CTX211, an allogeneic, gene-edited, hypoimmune stem cell-derived product candidate for the treatment of T1D. It has strategic partnerships with Vertex Pharmaceuticals Incorporated, Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.
Visit CRISPR Therapeutics AG WebsiteInvestment Thesis
CRISPR Therapeutics represents a high-risk, high-reward investment in a transformative biotech sector. Its pioneering gene-editing technology, the first-to-market CASGEVY, and a robust, advancing pipeline, all supported by a strengthened balance sheet, position it as a potential long-term leader in curing genetic diseases. Despite early commercialization challenges, insider selling, and valuation concerns, its long-term potential for market disruption remains significant.
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CRSP Price Targets & Strategy
12-Month Target
$90.00
Bull Case
$150.00
Bear Case
$35.00
Valuation Basis
Implied valuation based on projected pipeline success, increasing CASGEVY market penetration, and peer growth multiples applied to estimated future revenue streams, targeting early-stage commercial biotech valuations.
Entry Strategy
Consider dollar-cost averaging between $40-$48, taking advantage of current price near 52-week lows and below 50-day MA ($53.26).
Exit Strategy
Take partial profits at $90-$100, re-evaluate upon major pipeline catalysts. Implement a stop loss below $39.00 (below 52-week low of $30.04 to allow for volatility).
Portfolio Allocation
7-10% for aggressive risk tolerance
Price Targets & Strategy
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Is CRSP Financially Healthy?
Valuation
P/E Ratio
-7.09
Profitability
Return on Equity
-26.31%
Revenue Growth
-97.60%
EPS
$-1.37
Balance Sheet
Current Ratio
13.30
Debt/Equity
0.11
Total Debt
$550.00M
Other
Beta (Volatility)
1.72
Does CRSP Have a Competitive Moat?
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π‘οΈ Narrow
Moat Trend
Expanding
Moat Sources
3 Identified
CRISPR Therapeutics' moat is primarily derived from its foundational IP in gene editing and its early lead in bringing a therapy to market. This creates a significant head start, but patent challenges and emerging alternative technologies could erode its durability over the long term. Continued pipeline success and expansion of indications will strengthen this moat.
Moat Erosion Risks
- β’Potential invalidation or erosion of key IP through legal challenges
- β’Emergence of superior or more cost-effective gene-editing technologies from competitors
- β’Difficulty in scaling manufacturing or overcoming regulatory hurdles for new therapies
CRSP Competitive Moat Analysis
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CRSP Market Intelligence
Sentiment & Insider Activity
Social Sentiment
Neutral, with potential for increased retail interest on positive news.
Institutional Sentiment
Positive, indicated by analyst target raises from Piper Sandler and Chardan Capital, despite some Hold ratings.
Insider Activity (Form 4)
Negative: CEO and General Counsel among those who sold approximately 128,626 shares worth ~$7.13 million in the last 90 days.
Options Flow
Normal options activity.
Earnings Intelligence
Next Earnings
2026-05-06 (Q1 2026 estimated)
Surprise Probability
Medium
Historical Earnings Pattern
Specific historical earnings reaction patterns are not provided in the search results, but early-stage biotech stocks typically exhibit high volatility around clinical and commercial updates.
Key Metrics to Watch
Competitive Position
Top Competitor
Vertex Pharmaceuticals (VRTX)
Market Share Trend
Gaining (as a first-mover in approved gene-editing therapy for specific indications with CASGEVY).
Valuation vs Peers
Trading at a significant premium to traditional profitability metrics (negative P/E) but in line with early-stage, high-growth biotech based on future revenue potential. GF Valueβ’ indicates 'Significantly Overvalued' based on intrinsic value estimates.
Competitive Advantages
- β’Pioneering CRISPR/Cas9 technology and strong intellectual property portfolio
- β’First-mover advantage with an approved gene-editing therapy (CASGEVY)
- β’Strategic and commercial alliance with Vertex Pharmaceuticals for CASGEVY
Market Intelligence
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What Could Drive CRSP Stock Higher?
Near-Term (0-6 months)
- β’Q1 2026 Earnings on Wednesday, May 6, 2026
- β’CASGEVY pediatric regulatory filings (H1 2026)
- β’CTX340 Phase I initiation (H1 2026)
Medium-Term (6-18 months)
- β’Zugo-cel Phase I initiation (H2 2026)
- β’CTX460 Phase I initiation (mid-2026)
- β’Initial CASGEVY pediatric approvals and market launch
Long-Term (18+ months)
- β’Expansion of CASGEVY into additional indications or geographies
- β’Multiple new product approvals from diverse pipeline assets
- β’Industry leadership in *in vivo* gene editing therapies
Catalysts & Growth Drivers
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What's the Bull Case for CRSP?
- β
Acceleration in CASGEVY patient enrollment and revenue figures
- β
Positive clinical trial data for CTX programs, especially in oncology and *in vivo* applications
- β
New strategic partnerships or major milestone payments
Bull Case Analysis
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Competing with CRSP
See how CRISPR Therapeutics AG compares to related companies
| Company | Market Cap | DVR Score | P/E | Revenue | Profit Margin | Rev Growth | |
|---|---|---|---|---|---|---|---|
CRISPR Therapeutics AG CRSP | $4.4B | 8.6 | -7.1 | $3.5M | 0.0% | -97.6% | |
AbbVie Inc ABBV | $403.8B | 0.1 | 171.8 | β | β | β | Compare β |
Johnson & Johnson JNJ | β | 1.0 | β | β | β | β | Compare β |
Eli Lilly and Co LLY | $965.0B | 0.5 | 52.6 | β | β | β | Compare β |
Pfizer Inc PFE | $150.6B | 0.2 | 19.4 | $62.6B | 12.4% | -1.6% | Compare β |
UnitedHealth Group Inc UNH | $276.2B | 0.3 | 22.9 | $113.7B | 2.7% | 1181.0% | Compare β |
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FAQ
What is the DVR Score for CRISPR Therapeutics AG (CRSP)?
As of March 24, 2026, CRISPR Therapeutics AG has a DVR Score of 8.6 out of 10, placing it in the "Hidden Gem" category. This score is generated by our AI-powered deep value analysis framework that evaluates growth potential, financial health, competitive moat, and risk factors.
What is the market capitalization of CRISPR Therapeutics AG?
CRISPR Therapeutics AG's market capitalization is approximately $4.4B. The company operates in the Healthcare sector within the Biotechnology industry.
What ticker symbol does CRISPR Therapeutics AG use?
CRSP is the ticker symbol for CRISPR Therapeutics AG. The company trades on the NGM.
What is the risk level for CRSP stock?
Our analysis rates CRISPR Therapeutics AG's overall risk as Aggressive. This assessment considers execution risk, market risk, financial risk, competitive risk, and regulatory risk. For a full breakdown, see the risk analysis section above.
What is the P/E ratio of CRSP?
CRISPR Therapeutics AG currently has a price-to-earnings (P/E) ratio of -7.1. This is below the market average, which could indicate the stock is undervalued or facing headwinds.
Is CRISPR Therapeutics AG's revenue growing?
CRISPR Therapeutics AG has reported revenue growth of -97.6%. Revenue has been declining, which warrants closer examination.
Is CRSP stock profitable?
CRISPR Therapeutics AG has a profit margin of 0.0%. The company is currently unprofitable.
How often is the CRSP DVR analysis updated?
Our AI-powered analysis of CRISPR Therapeutics AG is refreshed regularly to incorporate the latest financial data, market conditions, and news. The most recent update was on March 24, 2026.
Important Disclaimer β Not Financial Advice
Deep Value Reports is an independent research platform for educational and informational purposes only. We are not financial advisors, investment advisors, or licensed professionals. The analysis, scores, and information provided on this page for CRSP (CRISPR Therapeutics AG) should not be construed as personalized investment advice, a recommendation to buy or sell any security, or an offer to provide investment advisory services.
All investments involve risk, including the potential loss of principal. Past performance does not guarantee future results. Always conduct your own research, consider your financial situation, and consult with a qualified financial advisor before making any investment decisions.