APLT Stock Risk & Deep Value Analysis

Applied Therapeutics Inc

Healthcare • Biotechnology

DVR Score

1.5

out of 10

Distressed

What You Need to Know About APLT Stock

We analyzed Applied Therapeutics Inc using our deep value framework. Sign in to see our full verdict and DVR Score.

We ran APLT through our deep value framework — analyzing financial health, distress signals, competitive moat, and risk factors. Our risk assessment: Aggressive. Here's what we found.

Updated Mar 1, 2026•Run Fresh Analysis →

How Risky Is APLT Stock?

Overall Risk

Aggressive

Financial Risk

High

Market Risk

High

Competitive Risk

Medium

Execution Risk

High

Regulatory Risk

High

What Are the Red Flags for APLT?

  • âš 

    Further dilutive financing at unfavorable terms

  • âš 

    Negative clinical trial results for pipeline candidates

  • âš 

    FDA rejection of AT-007 resubmission

  • âš 

    Potential delisting from NASDAQ due to low share price or market cap

  • âš 

    Bankruptcy filing

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What Does Applied Therapeutics Inc (APLT) Do?

Market Cap

$34.34M

Sector

Healthcare

Industry

Biotechnology

Employees

28

Applied Therapeutics, Inc., a clinical-stage biopharmaceutical company, engages in the development of a pipeline of novel product candidates against validated molecular targets in indications of high unmet medical need in the United States. The company's lead product candidate is AT-007 that has completed phase 3 for the treatment of galactosemia in healthy volunteers and adults, in pediatric clinical study for the treatment of galactosemia in kids, for treating enzyme sorbitol dehydrogenase, and for the treatment of phosphomannomutase enzyme-CDG. It develops AT-001 that is in phase 3 clinical trials to treat diabetic cardiomyopathy, as well as for the treatment of diabetic peripheral neuropathy; and AT-003, which is in preclinical studies for the treatment diabetic retinopathy. The company has exclusive license and supply agreement with Mercury Pharma Group Limited to commercialize drug products containing AT-007. Applied Therapeutics, Inc. was incorporated in 2016 and is headquartered in New York, New York.

Visit Applied Therapeutics Inc Website

Is APLT Stock Undervalued?

Applied Therapeutics (APLT) remains an extremely high-risk, highly speculative investment with a very low probability of achieving 10x growth within 3-5 years. Consistent with our previous assessment on 2026-02-10, no material positive changes have been publicly disclosed or are evident. The company continues to face severe financial distress, necessitating ongoing dilutive financing. The lead candidate AT-007 is still impacted by the April 2024 Complete Response Letter (CRL), with resubmission timelines uncertain (likely mid-2026). The total addressable market for SORD deficiency is niche, and other pipeline assets are too early-stage to provide near-term value. A substantial turnaround would require multiple improbable clinical and regulatory successes, alongside significant non-dilutive capital, none of which appear imminent. The current valuation reflects extreme investor skepticism and persistent operational challenges. The risk of further significant capital impairment or delisting remains high.

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Does APLT Have a Competitive Moat?

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Moat Rating

⚪ None

Moat Trend

Eroding

Moat Sources

1 Identified

Intangible Assets/IP

APLT's 'moat,' primarily its intellectual property, is highly fragile and currently non-durable due to significant regulatory hurdles, financial instability, and lack of commercial success. Without regulatory approval and a clear path to market, the IP provides very little defensible advantage.

Moat Erosion Risks

  • •Clinical trial failure or regulatory rejection of AT-007
  • •Inability to secure sufficient non-dilutive funding
  • •Competitors developing superior or faster-to-market treatments
  • •Loss of key personnel or scientific talent

APLT Competitive Moat Analysis

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What Could Drive APLT Stock Higher?

Near-Term (0-6 months)

  • •Q4 2025 Earnings Report (Estimated mid-March 2026)
  • •Potential dilutive financing announcement

Medium-Term (6-18 months)

  • •AT-007 resubmission for SORD deficiency to FDA (Likely mid-2026)
  • •FDA action on AT-007 resubmission (late 2026 / early 2027)
  • •Initial data from earlier-stage pipeline assets

Long-Term (18+ months)

  • •AT-007 FDA approval and commercial launch
  • •Significant pipeline advancement in other indications

Catalysts & Growth Drivers

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What's the Bull Case for APLT?

  • ✓

    Positive FDA decision on AT-007 resubmission and approval

  • ✓

    Announcement of significant non-dilutive financing or strategic partnership

  • ✓

    Substantial improvement in cash runway and burn rate

  • ✓

    Positive clinical data from other pipeline programs

Bull Case Analysis

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Compare APLT to Similar Stocks

See how Applied Therapeutics Inc stacks up against related companies in our head-to-head analysis.

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Important Disclaimer – Not Financial Advice

Deep Value Reports is an independent research platform for educational and informational purposes only. We are not financial advisors, investment advisors, or licensed professionals. The analysis, scores, and information provided on this page for APLT (Applied Therapeutics Inc) should not be construed as personalized investment advice, a recommendation to buy or sell any security, or an offer to provide investment advisory services.

All investments involve risk, including the potential loss of principal. Past performance does not guarantee future results. Always conduct your own research, consider your financial situation, and consult with a qualified financial advisor before making any investment decisions.

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